Figuring out how our cells keep it together

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Highlighted

An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
Nicholas R. Ader, Linda Chen1, Ivan V. Surovtsev, William L. Chadwick, Elisa C. Rodriguez, Megan C. King, C. Patrick Lusk
Nature Cell Biology  ·  01 Oct 2023  ·  doi:10.1038/s41556-023-01235-4
1Undergraduate researcher
research article

All

2026

Supplementary Tables from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Supplementary Tables from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714812
Supplementary Movie SM4 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Supplementary Movie SM4 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714815
Supplementary Movie SM3 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Supplementary Movie SM3 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714818
Supplementary Movie SM2 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Supplementary Movie SM2 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714821
Supplementary Movie SM1 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Supplementary Movie SM1 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714824
Supplementary Methods from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Supplementary Methods from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714827
Figure S9 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S9 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714830
Figure S8 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S8 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714833
Figure S7 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S7 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714836
Figure S6 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S6 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714839
Figure S5 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S5 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714842
Figure S4 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S4 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714845
Figure S3 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S3 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714851
Figure S2 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S2 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714854
Figure S12 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S12 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714857
Figure S11 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S11 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714860
Figure S10 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S10 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714863
Figure S1 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Figure S1 from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.32714872
Data from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Data from Loss of JAK1 Function Causes G<sub>2</sub>–M Cell-Cycle Defects Vulnerable to KIF18A Inhibition
Vanessa M. Kelley, Marta Baro, William E. Gasperi, Nicholas R. Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan C. King, Joseph N. Contessa
American Association for Cancer Research (AACR)  ·  17 Jun 2026  ·  doi:10.1158/0008-5472.c.8542720
Cmp7-dependent recruitment of Alx1 to a mitotic nuclear envelope hole in Schizosaccharomyces pombe
Cmp7-dependent recruitment of Alx1 to a mitotic nuclear envelope hole in Schizosaccharomyces pombe
Kaela D. Genereux, Olivia N. Walker, Sage O. Benders, Thanh Truc Le, Nicholas R. Ader
microPublication Biology  ·  01 Jan 2026  ·  doi:10.17912/MICROPUB.BIOLOGY.002122

2025

Sense, plug, and seal: proteins as both rapid responders and constitutive barriers supporting organelle compartmentalization
Sense, plug, and seal: proteins as both rapid responders and constitutive barriers supporting organelle compartmentalization
Megan C. King, C. Patrick Lusk, Nicholas R. Ader
Molecular Biology of the Cell  ·  01 Aug 2025  ·  doi:10.1091/mbc.e23-08-0307
Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to Kif18a Inhibition
Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to Kif18a Inhibition
Vanessa Kelley, Marta Baro, William Gasperi, Nicholas Ader, Hannah Lea, Hojin Lee, Chatchai Phoomak, Lilian Kabeche, Megan King, Joseph Contessa
openRxiv  ·  24 Feb 2025  ·  doi:10.1101/2025.02.19.638911
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
Philip J. Mannino, Andrew Perun, Ivan V. Surovtsev, Nicholas R. Ader, Lin Shao, Elisa C. Rodriguez, Thomas J. Melia, Megan C. King, C. Patrick Lusk
Nature Cell Biology  ·  07 Feb 2025  ·  doi:10.1038/s41556-025-01612-1
research article

2023

An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
Nicholas R. Ader, Linda Chen1, Ivan V. Surovtsev, William L. Chadwick, Elisa C. Rodriguez, Megan C. King, C. Patrick Lusk
Nature Cell Biology  ·  01 Oct 2023  ·  doi:10.1038/s41556-023-01235-4
1Undergraduate researcher
research article

2021

Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome
Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome
Sunandini Chandra, Philip J. Mannino, David J. Thaller, Nicholas R. Ader, Megan C. King, Thomas J. Melia, C. Patrick Lusk
Journal of Cell Biology  ·  29 Oct 2021  ·  doi:10.1083/jcb.202103030
research article
Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations
Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations
David J. Thaller, Danqing Tong, Christopher J. Marklew, Nicholas R. Ader, Philip J. Mannino, Sapan Borah, Megan C. King, Barbara Ciani, C. Patrick Lusk
Journal of Cell Biology  ·  19 Jan 2021  ·  doi:10.1083/jcb.202004222
research article

2020

CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier
CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier
C. Patrick Lusk, Nicholas R. Ader
Current Opinion in Cell Biology  ·  01 Jun 2020  ·  doi:10.1016/j.ceb.2020.01.011
review

2019

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis
Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis
Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski
eLife  ·  04 Feb 2019  ·  doi:10.7554/elife.40712
research article

2017

triCLEM- Combining high-precision, room temperature CLEM with cryo-fluorescence microscopy to identify very rare events
triCLEM- Combining high-precision, room temperature CLEM with cryo-fluorescence microscopy to identify very rare events
Methods in Cell Biology  ·  01 Jan 2017  ·  doi:10.1016/bs.mcb.2017.03.009
method article

2016

Seeking an<i>In Vivo</i>Neuronal Context for the PINK1/Parkin Pathway
Seeking anIn VivoNeuronal Context for the PINK1/Parkin Pathway
Nicholas R. Ader
The Journal of Neuroscience  ·  02 Nov 2016  ·  doi:10.1523/jneurosci.2525-16.2016
commentary

2015

Comparison of human Nrf2 antibodies: A tale of two proteins
Comparison of human Nrf2 antibodies: A tale of two proteins
Zachary A. Kemmerer, Nicholas R. Ader, Sarah S. Mulroy, Aimee L. Eggler
Toxicology Letters  ·  01 Oct 2015  ·  doi:10.1016/j.toxlet.2015.07.004
research article

2014

Direct Synthesis of Partially Modified 2′‐ <i>O</i> ‐Pivaloyloxymethyl RNAs by a Base‐Labile Protecting Group Strategy and their Potential for Prodrug‐Based Gene‐Silencing Applications
Direct Synthesis of Partially Modified 2′‐ O ‐Pivaloyloxymethyl RNAs by a Base‐Labile Protecting Group Strategy and their Potential for Prodrug‐Based Gene‐Silencing Applications
Annabelle Biscans, Maxence Bos, Anthony R. Martin, Nicholas Ader, Georg Sczakiel, Jean‐Jacques Vasseur, Christelle Dupouy, Françoise Debart
ChemBioChem  ·  24 Oct 2014  ·  doi:10.1002/cbic.201402382
research article