Figuring out how our cells keep it together

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An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
Nicholas R. Ader, Linda Chen1, Ivan V. Surovtsev, William L. Chadwick, Elisa C. Rodriguez, Megan C. King, C. Patrick Lusk
Nature Cell Biology  ·  01 Oct 2023  ·  doi:10.1038/s41556-023-01235-4
1Undergraduate researcher
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2024

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
Philip J Mannino, Andrew Perun, Ivan Surovstev, Nicholas R Ader, Lin Shao, Elisa C Rodriguez, Thomas Melia, Megan C King, C. Patrick Lusk
bioRxiv  ·  15 Feb 2024  ·  doi:10.1101/2024.02.14.580336
research article preprint

2023

An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
Nicholas R. Ader, Linda Chen1, Ivan V. Surovtsev, William L. Chadwick, Elisa C. Rodriguez, Megan C. King, C. Patrick Lusk
Nature Cell Biology  ·  01 Oct 2023  ·  doi:10.1038/s41556-023-01235-4
1Undergraduate researcher
research article

2021

Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome
Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome
Sunandini Chandra, Philip J. Mannino, David J. Thaller, Nicholas R. Ader, Megan C. King, Thomas J. Melia, C. Patrick Lusk
Journal of Cell Biology  ·  29 Oct 2021  ·  doi:10.1083/jcb.202103030
research article
Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations
Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations
David J. Thaller, Danqing Tong, Christopher J. Marklew, Nicholas R. Ader, Philip J. Mannino, Sapan Borah, Megan C. King, Barbara Ciani, C. Patrick Lusk
Journal of Cell Biology  ·  19 Jan 2021  ·  doi:10.1083/jcb.202004222
research article

2020

2019

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis
Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis
Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski
eLife  ·  04 Feb 2019  ·  doi:10.7554/elife.40712
research article

2017

2016

2015

Comparison of human Nrf2 antibodies: A tale of two proteins
Comparison of human Nrf2 antibodies: A tale of two proteins
Zachary A. Kemmerer, Nicholas R. Ader, Sarah S. Mulroy, Aimee L. Eggler
Toxicology Letters  ·  01 Oct 2015  ·  doi:10.1016/j.toxlet.2015.07.004
research article

2014

Direct Synthesis of Partially Modified 2′‐<i>O</i>‐Pivaloyloxymethyl RNAs by a Base‐Labile Protecting Group Strategy and their Potential for Prodrug‐Based Gene‐Silencing Applications
Direct Synthesis of Partially Modified 2′‐O‐Pivaloyloxymethyl RNAs by a Base‐Labile Protecting Group Strategy and their Potential for Prodrug‐Based Gene‐Silencing Applications
Annabelle Biscans, Maxence Bos, Anthony R. Martin, Nicholas Ader, Georg Sczakiel, Jean‐Jacques Vasseur, Christelle Dupouy, Françoise Debart
ChemBioChem  ·  24 Oct 2014  ·  doi:10.1002/cbic.201402382
research article